| Name: | Duloxetine EP Impurity A |
| Catalogue No. | VL202001 |
| CAS No. | 116539-60-7 |
| Molecular Formula | C18H19NOS |
| Molecular Weight | 297.41 |
| Status | In-stock |
| IUPAC Name | (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan- 1-amine |
| Synonyms | Duloxetine (R)-Isomer |
| Description | Duloxetine EP Impurity A or Duloxetine Related Compound A/ Duloxetine (R)-Isomer (CAS No.116539-60-7) or (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan- 1-amine. Duloxetine is a potent reuptake inhibitor of serotonin(5-HT) and norepinephrine. It is used in the treatment of depression, diabetic neuropathic pain, anxiety, fibromyalgia. It is an moderate inhibitor of CYP2D6. It is extensively metabolized by Cytochrome p450. |
| References | "Knadler, Mary Pat, et al. “Duloxetine.” Clinical Pharmacokinetics, vol. 50, no. 5, May 2011, pp. 281–94, https://doi.org/10.2165/11539240-000000000-00000. Carter, Natalie J., and Paul L. McCormack. “Duloxetine.” CNS Drugs, vol. 23, no. 6, May 2009, pp. 523–41, https://doi.org/10.2165/00023210-200923060-00006. " |
