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Duloxetine EP Impurity A

Duloxetine EP Impurity A

Catalogue No.: VL202001
CAS No.: 116539-60-7

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Name: Duloxetine EP Impurity A
Catalogue No. VL202001
CAS No. 116539-60-7
Molecular Formula C18H19NOS
Molecular Weight 297.41
Status In-stock
IUPAC Name (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan- 1-amine
Synonyms Duloxetine (R)-Isomer
Description Duloxetine EP Impurity A or Duloxetine Related Compound A/ Duloxetine (R)-Isomer (CAS No.116539-60-7) or (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan- 1-amine. Duloxetine is a potent reuptake inhibitor of serotonin(5-HT) and norepinephrine. It is used in the treatment of depression, diabetic neuropathic pain, anxiety, fibromyalgia. It is an moderate inhibitor of CYP2D6. It is extensively metabolized by Cytochrome p450.
References "Knadler, Mary Pat, et al. “Duloxetine.” Clinical Pharmacokinetics, vol. 50, no. 5, May 2011, pp. 281–94, https://doi.org/10.2165/11539240-000000000-00000. Carter, Natalie J., and Paul L. McCormack. “Duloxetine.” CNS Drugs, vol. 23, no. 6, May 2009, pp. 523–41, https://doi.org/10.2165/00023210-200923060-00006. ‌"

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