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Duloxetine EP Impurity A HCl salt

Duloxetine EP Impurity A HCl salt

Catalogue No.: VE006832
CAS No.: 910138-96-4

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Name: Duloxetine EP Impurity A HCl salt
Catalogue No. VE006832
CAS No. 910138-96-4
Molecular Formula C18H20ClNOS
Molecular Weight 333.88
Status In-stock
IUPAC Name (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine HCl
Synonyms Duloxetine Related Compound A/ Duloxetine R-Isomer (HCl salt)
Description Duloxetine EP Impurity A HCl salt or Duloxetine Related Compound A/ Duloxetine R-Isomer (HCl salt) (CAS No.910138-96-4) or (3R)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine HCl. Duloxetine is a potent reuptake inhibitor of serotonin(5-HT) and norepinephrine. It is used in the treatment of depression, diabetic neuropathic pain, anxiety, fibromyalgia. It is an moderate inhibitor of CYP2D6. It is extensively metabolized by Cytochrome p450.
References "Knadler, Mary Pat, et al. “Duloxetine.” Clinical Pharmacokinetics, vol. 50, no. 5, May 2011, pp. 281–94, https://doi.org/10.2165/11539240-000000000-00000. Carter, Natalie J., and Paul L. McCormack. “Duloxetine.” CNS Drugs, vol. 23, no. 6, May 2009, pp. 523–41, https://doi.org/10.2165/00023210-200923060-00006. ‌"

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