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Duloxetine EP Impurity C

Duloxetine EP Impurity C

Catalogue No.: VL202012
CAS No.: 949096-01-9

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Name: Duloxetine EP Impurity C
Catalogue No. VL202012
CAS No. 949096-01-9
Molecular Formula C18H19NOS. HCl
Molecular Weight 297.41
Status In-stock
IUPAC Name 4-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl]naphthalen-1- ol HCl
Synonyms Duloxetine 4-Napthyl Isomer (HCl salt)
Appearance Off White Powder
Description Duloxetine EP Impurity C or Duloxetine 4-Napthyl Isomer (CAS No.949096-01-9) or 4-[(1RS)-3-(Methylamino)-1-(thiophen-2-yl)propyl]naphthalen-1- ol HCl. Duloxetine is a potent reuptake inhibitor of serotonin(5-HT) and norepinephrine. It is used in the treatment of depression, diabetic neuropathic pain, anxiety, fibromyalgia. It is an moderate inhibitor of CYP2D6. It is extensively metabolized by Cytochrome p450.
References "Carter, Natalie J., and Paul L. McCormack. “Duloxetine.” CNS Drugs, vol. 23, no. 6, May 2009, pp. 523–41, https://doi.org/10.2165/00023210-200923060-00006. ‌Knadler, Mary Pat, et al. “Duloxetine.” Clinical Pharmacokinetics, vol. 50, no. 5, May 2011, pp. 281–94, https://doi.org/10.2165/11539240-000000000-00000."

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