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Duloxetine Nitroso Impurity

Duloxetine Nitroso Impurity

Catalogue No.: VE007668
CAS No.: N/A

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Name: Duloxetine Nitroso Impurity
Catalogue No. VE007668
CAS No. N/A
Molecular Formula C18H18N2O2S
Molecular Weight 326.41 g/mol
Status In-Stock
IUPAC Name (S)-N-methyl-N-(3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl)nitrous amide
Description Duloxetine Nitroso Impurity or (S)-N-methyl-N-(3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propyl)nitrous amide. Duloxetine is a potent reuptake inhibitor of serotonin(5-HT) and norepinephrine. It is used in the treatment of depression, diabetic neuropathic pain, anxiety, fibromyalgia. It is an moderate inhibitor of CYP2D6. It is extensively metabolized by Cytochrome p450.
References "Carter, Natalie J., and Paul L. McCormack. “Duloxetine.” CNS Drugs, vol. 23, no. 6, May 2009, pp. 523–41, https://doi.org/10.2165/00023210-200923060-00006. ‌ Knadler, Mary Pat, et al. “Duloxetine.” Clinical Pharmacokinetics, vol. 50, no. 5, May 2011, pp. 281–94, https://doi.org/10.2165/11539240-0

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