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Entacapone Amide Impurity

Entacapone Amide Impurity

Catalogue No.: VL2400006
CAS No.: 158693-01-7

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Name: Entacapone Amide Impurity
Catalogue No. VL2400006
CAS No. 158693-01-7
Molecular Formula C10H7N3O5
Molecular Weight 249.18
Status In-stock
IUPAC Name (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide
Appearance Yellow Powder
Description Entacapone Amide Impurity (CAS No.158693-01-7) or (E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylamide. Entacapone is a potent and specific peripheral catechol-o-methyltransferase inhibitor (COMT) inhibitor. It is used in the treatment of parkinsons disease.The Z isomer of entacapone is the important metabolite in human plasma.
References "Schrag, Anette. “Entacapone in the Treatment of Parkinson’s Disease.” The Lancet Neurology, vol. 4, no. 6, June 2005, pp. 366–70, https://doi.org/10.1016/s1474-4422(05)70098-3. ‌ Holm, Kristin J., and Caroline M. Spencer. “Entacapone.” Drugs, vol. 58, no. 1, 1999, pp. 159–77, https://doi.org/10.2165/00003495-199958010-00017. ‌"

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