| Name: | Entacapone EP Impurity A |
| Catalogue No. | VL2400007 |
| CAS No. | 145195-63-7 |
| Molecular Formula | C14H15N3O5 |
| Molecular Weight | 305.29 |
| Status | In-stock |
| IUPAC Name | (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide |
| Description | Entacapone EP Impurity A (CAS No.145195-63-7) or (Z)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylacrylamide. Entacapone is a potent and specific peripheral catechol-o-methyltransferase inhibitor (COMT) inhibitor. It is used in the treatment of parkinsons disease.The Z isomer of entacapone is the important metabolite in human plasma. |
| References | "Schrag, Anette. “Entacapone in the Treatment of Parkinson’s Disease.” The Lancet Neurology, vol. 4, no. 6, June 2005, pp. 366–70, https://doi.org/10.1016/s1474-4422(05)70098-3. Holm, Kristin J., and Caroline M. Spencer. “Entacapone.” Drugs, vol. 58, no. 1, 1999, pp. 159–77, https://doi.org/10.2165/00003495-199958010-00017. " |
