| Name: | Entacapone EP Impurity I |
| Catalogue No. | VL2400009 |
| CAS No. | 1364322-42-8 |
| Molecular Formula | C13H12N2O6 |
| Molecular Weight | 292.25 |
| Status | In-stock |
| IUPAC Name | propyl (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylate |
| Description | Entacapone EP Impurity I (CAS No.1364322-42-8) or propyl (E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)acrylate. Entacapone is a potent and specific peripheral catechol-o-methyltransferase inhibitor (COMT) inhibitor. It is used in the treatment of parkinsons disease.The Z isomer of entacapone is the important metabolite in human plasma. |
| References | "Holm, Kristin J., and Caroline M. Spencer. “Entacapone.” Drugs, vol. 58, no. 1, 1999, pp. 159–77, https://doi.org/10.2165/00003495-199958010-00017. Schrag, Anette. “Entacapone in the Treatment of Parkinson’s Disease.” The Lancet Neurology, vol. 4, no. 6, June 2005, pp. 366–70, https://doi.org/10.1016/s1474-4422(05)70098-3. " |
