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Entacapone Impurity 4

Entacapone Impurity 4

Catalogue No.: VL2400012
CAS No.: 1202160-40-4

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Name: Entacapone Impurity 4
Catalogue No. VL2400012
CAS No. 1202160-40-4
Molecular Formula C11H8N2O6
Molecular Weight 264.19
Status In-stock
IUPAC Name (E)-2-cyano-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylic acid
Description Entacapone Impurity 4 (CAS No.1202160-40-4) or (E)-2-cyano-3-(4-hydroxy-3-methoxy-5-nitrophenyl)acrylic acid. Entacapone is a potent and specific peripheral catechol-o-methyltransferase inhibitor (COMT) inhibitor. It is used in the treatment of parkinsons disease.The Z isomer of entacapone is the important metabolite in human plasma.
References "Schrag, Anette. “Entacapone in the Treatment of Parkinson’s Disease.” The Lancet Neurology, vol. 4, no. 6, June 2005, pp. 366–70, https://doi.org/10.1016/s1474-4422(05)70098-3. ‌Holm, Kristin J., and Caroline M. Spencer. “Entacapone.” Drugs, vol. 58, no. 1, 1999, pp. 159–77, https://doi.org/10.2165/00003495-199958010-00017. ‌"

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