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Fluoro Desloratadine

Fluoro Desloratadine

Catalogue No.: VL41008
CAS No.: 298220-99-2

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Name: Fluoro Desloratadine
Catalogue No. VL41008
CAS No. 298220-99-2
Molecular Formula C₁₉H₂₀ClFN₂
Molecular Weight 330.83
Status In-stock
IUPAC Name 8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
Description Fluoro Desloratadine (CAS No.: 298220-99-2) or 8-Chloro-11-fluoro-6,11-dihydro-11-(4-piperidinyl)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine is a fluoro derivative of Desloratadine which is a selective H1-receptor inhibitor and also depicts anti-inflammatory activity. Desloratadine blocks the release of multiple inflammatory mediators IL-4, IL-6, IL-8, IL-13, PGD2.
References Zheng, Jinjian, and Abu M. Rustum. “Rapid Separation of Desloratadine and Related Compounds in Solid Pharmaceutical Formulation Using Gradient Ion-Pair Chromatography.” Journal of Pharmaceutical and Biomedical Analysis, vol. 51, no. 1, Jan. 2010, pp. 146–52,https://doi.org/10.1016/j.jpba.2009.08.024.‌Geha, Raif S., and Eli O. Meltzer. “Desloratadine: A New, Nonsedating, Oral Antihistamine.” Journal of Allergy and Clinical Immunology, vol. 107, no. 4, Apr. 2001, pp. 751–62,https://doi.org/10.1067

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