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Metoprolol EP Impurity F

Metoprolol EP Impurity F

Catalogue No.: VL103013
CAS No.: 7695-63-8

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Name: Metoprolol EP Impurity F
Catalogue No. VL103013
CAS No. 7695-63-8
Molecular Formula C₁₂H₁₉NO₂
Molecular Weight 209.28
Status In-stock
IUPAC Name (2RS)-1-[(1-Methylethyl)amino]-3-phenoxypropan-2-ol
Synonyms Metoprolol Succinate EP Impurity F/ Metoprolol Tartarate EP Impurity F
Appearance White to Off white Solid powder
Description Metoprolol EP Impurity F (CAS No: 7695-63-8) or Metoprolol Succinate EP Impurity F/ Metoprolol Tartarate EP Impurity F (1-Isopropylamino-3-phenoxypropan-2-ol) is an impurity present in metoprolol which is of therapeutic value in the treatment of various cardiovascular disorders, such as angina pectoris, cardiac arrhythmia. Physicochemical nature shows a membrane-stabilizing effect, a local anesthetic action as well as a cardio depressant effect.
References Erickson, Magnus, et al. “Identification of a New By-Product Detected in Metoprolol Tartrate.” Journal of Pharmaceutical and Biomedical Analysis, vol. 13, no. 4-5, Apr. 1995, pp. 567–74, https://doi.org/10.1016/0731-7085(95)01277-r. Winkler, Horst, et al. “High-Performance Liquid Chromatographic Method for the Quantitative Analysis of the Aryloxypropanolamines Propranolol, Metoprolol and Atenolol in Plasma and Tissue.” Journal of Chromatography B: Biomedical Sciences and Applications, vol. 228,

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