| Name: | Mometasone Furoate EP Impurity H |
| Catalogue No. | VL4080008 |
| CAS No. | 148596-90-1 |
| Molecular Formula | C₂₇H₃₁ClO₇ |
| Molecular Weight | 502.98 |
| Status | In-stock |
| IUPAC Name | :(11β,16α)-9-Chloro-17-[(2-furanylcarbonyl)oxy]-11,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione |
| Description | Mometasone Furoate EP Impurity H (CAS No: 148596-90-1) is an impurity present in the synthesis of mometasone which is a well-tolerated intranasal corticosteroid with minimal systemic activity and onset of action of ≤7 hours. It is useful in the prophylaxis and treatment of seasonal allergic rhinitis and perennial allergic rhinitis in patients with moderate to severe symptoms. |
| References | Das, Saibal Kumar, et al. “Improvements in Corticosteroid 21-Acetoxy-17α-Hydroxy-16α-Methyl-Pregna-1,4,9(11)-Triene-3,20-Dione Synthesis and Its Use as Common Intermediate in the Synthesis of Some Impurities Related to Dexamethasone and Mometasone.” Steroids, vol. 148, Aug. 2019, pp. 47–55, https://doi.org/10.1016/j.steroids.2019.04.008. Onrust, Susan V., and Harriet M. Lamb. “Mometasone Furoate.” Drugs, vol. 56, no. 4, 1998, pp. 725–45,https://doi.org/10.2165/00003495-199856040-00018. |
