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Mometasone Furoate EP Impurity H

Mometasone Furoate EP Impurity H

Catalogue No.: VL4080008
CAS No.: 148596-90-1

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Name: Mometasone Furoate EP Impurity H
Catalogue No. VL4080008
CAS No. 148596-90-1
Molecular Formula C₂₇H₃₁ClO₇
Molecular Weight 502.98
Status In-stock
IUPAC Name :(11β,16α)-9-Chloro-17-[(2-furanylcarbonyl)oxy]-11,21-dihydroxy-16-methyl-pregna-1,4-diene-3,20-dione
Description Mometasone Furoate EP Impurity H (CAS No: 148596-90-1) is an impurity present in the synthesis of mometasone which is a well-tolerated intranasal corticosteroid with minimal systemic activity and onset of action of ≤7 hours. It is useful in the prophylaxis and treatment of seasonal allergic rhinitis and perennial allergic rhinitis in patients with moderate to severe symptoms.
References Das, Saibal Kumar, et al. “Improvements in Corticosteroid 21-Acetoxy-17α-Hydroxy-16α-Methyl-Pregna-1,4,9(11)-Triene-3,20-Dione Synthesis and Its Use as Common Intermediate in the Synthesis of Some Impurities Related to Dexamethasone and Mometasone.” Steroids, vol. 148, Aug. 2019, pp. 47–55, https://doi.org/10.1016/j.steroids.2019.04.008. Onrust, Susan V., and Harriet M. Lamb. “Mometasone Furoate.” Drugs, vol. 56, no. 4, 1998, pp. 725–45,https://doi.org/10.2165/00003495-199856040-00018.

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