| Name: | Montelukast Dihydro Impurity |
| Catalogue No. | VL510008 |
| CAS No. | 142147-67-9 |
| Molecular Formula | C₃₅H₃₇ClNNaO₃S |
| Molecular Weight | 610.18 |
| Status | In-stock |
| IUPAC Name | (R)-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid |
| Appearance | Light Orange Powder |
| Description | Montelukast Dihydro Impurity (CAS No: 142147-67-9) is an impurity present in montelukast which is cysteinyl leukotriene (CysLT) 1 receptor antagonist used in asthma treatment, decreases eosinophil infiltration into the asthmatic airways, suggesting that CysLTs modulate eosinophil protease activity. |
| References | Barnabas, K. Samuel, et al. “A Novel Stability-Indicating Method for Determination of Related Substances of Montelukast Sodium in a Pharmaceutical Dosage Form Using RP-HPLC.” Chromatographia, vol. 84, no. 7, June 2021, pp. 645–62, https://doi.org/10.1007/s10337-021-04045-8. Langlois, Anick, et al. “Montelukast Regulates Eosinophil Protease Activity through a Leukotriene-Independent Mechanism.” Journal of Allergy and Clinical Immunology, vol. 118, no. 1, July 2006, pp. 113–19, https://doi.org/1 |
