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Montelukast Dihydro Impurity

Montelukast Dihydro Impurity

Catalogue No.: VL510008
CAS No.: 142147-67-9

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Name: Montelukast Dihydro Impurity
Catalogue No. VL510008
CAS No. 142147-67-9
Molecular Formula C₃₅H₃₇ClNNaO₃S
Molecular Weight 610.18
Status In-stock
IUPAC Name (R)-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic Acid
Appearance Light Orange Powder
Description Montelukast Dihydro Impurity (CAS No: 142147-67-9) is an impurity present in montelukast which is cysteinyl leukotriene (CysLT) 1 receptor antagonist used in asthma treatment, decreases eosinophil infiltration into the asthmatic airways, suggesting that CysLTs modulate eosinophil protease activity.
References Barnabas, K. Samuel, et al. “A Novel Stability-Indicating Method for Determination of Related Substances of Montelukast Sodium in a Pharmaceutical Dosage Form Using RP-HPLC.” Chromatographia, vol. 84, no. 7, June 2021, pp. 645–62, https://doi.org/10.1007/s10337-021-04045-8. ‌Langlois, Anick, et al. “Montelukast Regulates Eosinophil Protease Activity through a Leukotriene-Independent Mechanism.” Journal of Allergy and Clinical Immunology, vol. 118, no. 1, July 2006, pp. 113–19, https://doi.org/1

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