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Montelukast EP Impurity E

Montelukast EP Impurity E

Catalogue No.: VE006806
CAS No.: 1187586-58-8

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Name: Montelukast EP Impurity E
Catalogue No. VE006806
CAS No. 1187586-58-8
Molecular Formula C41H46ClNO5S2
Molecular Weight 732.39
Status In-stock
IUPAC Name 1-[[[(1R)-1-[3-[(1S)-1-[[[1-(Carboxymethyl)cyclopropyl]methyl]thio]-2-(7-chloro-2-quinolinyl)ethyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl) phenyl] propyl] thio]methyl]-cyclopropaneacetic acid
Synonyms Montelukast Related Compound D/ Michael Adduct (R,S)-Isomer
Description Montelukast EP Impurity E (CAS No: 1187586-58-8) or Montelukast Related Compound D is an impurity present in montelukast which is used as effective adjuvant therapy in pregnant women only in cases where resistance to other asthma treatments and effectiveness have been established prior to pregnancy.
References Emerce, Esra, et al. “Determination of the Impurities in Drug Products Containing Montelukast and in Silico/in Vitro Genotoxicological Assessments of Sulfoxide Impurity.” Toxicology Letters, vol. 238, no. 2, Oct. 2015, pp. 90–99, https://doi.org/10.1016/j.toxlet.2015.07.003. Sarkar, Moumita, et al. “Montelukast Use during Pregnancy: A Multicentre, Prospective, Comparative Study of Infant Outcomes.” European Journal of Clinical Pharmacology, vol. 65, no. 12, Aug. 2009, pp. 1259–64, https://doi.o

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