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Montelukast Methyl Ketone Impurity

Montelukast Methyl Ketone Impurity

Catalogue No.: VL510002
CAS No.: 937275-23-5

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Name: Montelukast Methyl Ketone Impurity
Catalogue No. VL510002
CAS No. 937275-23-5
Molecular Formula C₃₄H₃₂ClNO₃S
Molecular Weight 570.14
Status In-stock
IUPAC Name 1-[[[(1R)-3-(2-Acetylphenyl)-1-[3-[(1E)-2-(7-chloro-2-quinolinyl)ethenyl]phenyl]propyl]thio]methyl]c
Synonyms Montelukast EP Impurity F / Montelukast USP Related Compound E / Montelukast Methylketone
Appearance Light orange powder
Description Montelukast Methylketone Impurity (CAS No: 937275-23-5) or Montelukast USP Related Compound E is an impurity present in montelukast which is approved as a treatment for intermittent and persistent allergic rhinitis (AR), can induce bronchoconstriction, increase microvascular permeability.
References Emerce, Esra, et al. “Determination of the Impurities in Drug Products Containing Montelukast and in Silico/in Vitro Genotoxicological Assessments of Sulfoxide Impurity.” Toxicology Letters, vol. 238, no. 2, Oct. 2015, pp. 90–99, https://doi.org/10.1016/j.toxlet.2015.07.003. ‌Ciebiada, Maciej, et al. “Montelukast with Desloratadine or Levocetirizine for the Treatment of Persistent Allergic Rhinitis.” Annals of Allergy, Asthma & Immunology, vol. 97, no. 5, Nov. 2006, pp. 664–71, https://doi.org/

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