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Nebivolol RRRR

Nebivolol RRRR

Catalogue No.: VL490020
CAS No.: N/A

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Name: Nebivolol RRRR
Catalogue No. VL490020
Molecular Formula C22H25F2NO9
Molecular Weight 405.43
Status In-stock
IUPAC Name (R,1R,1’R)-2-2’azanediylbis(1-( R)-6-flurochroman-2-yl)ethanol
Description Nebivolol RRRR is an impurity present in Nebivolol which is a cardioselective β-blocker that has been reported to be efficacious and well-tolerated for achieving BP control in patients with hypertension. Preliminary evidence suggests a potential for reduced mortality in patients with heart failure.
References Chandrasekhar, S. “Enantioselective Total Synthesis of the Antihypertensive Agent (S,R,R,R)-Nebivolol.” Tetrahedron, vol. 56, no. 34, Aug. 2000, pp. 6339–44,https://doi.org/10.1016/s0040-4020(00)00572-x.Cheng, Judy W. M. “Nebivolol: A Third-Generation β-Blocker for Hypertension.” Clinical Therapeutics, vol. 31, no. 3, Mar. 2009, pp. 447–62,https://doi.org/10.1016/j.clinthera.2009.03.007.‌

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