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O-Desethyl Dapagliflozin

O-Desethyl Dapagliflozin

Catalogue No.: VL1650009
CAS No.: 864070-37-1

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Name: O-Desethyl Dapagliflozin
Catalogue No. VL1650009
CAS No. 864070-37-1
Molecular Formula C19H21ClO6
Molecular Weight 380.82
Status In-stock
IUPAC Name (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-D-glucitol
Appearance White solid
Description O-Desethyl Dapagliflozin (CAS No.: 864070-37-1) or (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-D-glucitol is a heteroaryls metabolite of Dapagliflozin which is an SGLT2 inhibitor useful in the treatment of Type-2 diabetes. Dapagliflozin diminishes the risk of worsening heart failure (HF) and death in patients having HF and lowered ejection fraction.
References Haider, Kashif, et al. “Synthetic Strategy and SAR Studies of C-Glucoside Heteroaryls as SGLT2 Inhibitor: A Review.” European Journal of Medicinal Chemistry, vol. 184, Dec. 2019, p. 111773,https://doi.org/10.1016/j.ejmech.2019.111773.‌Docherty, Kieran F., et al. “Effects of Dapagliflozin in DAPA-HF according to Background Heart Failure Therapy.” European Heart Journal, vol. 41, no. 25, Mar. 2020, pp. 2379–92,https://doi.org/10.1093/eurheartj/ehaa183.‌

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