| Name: | O-Desethyl Dapagliflozin |
| Catalogue No. | VL1650009 |
| CAS No. | 864070-37-1 |
| Molecular Formula | C19H21ClO6 |
| Molecular Weight | 380.82 |
| Status | In-stock |
| IUPAC Name | (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-D-glucitol |
| Appearance | White solid |
| Description | O-Desethyl Dapagliflozin (CAS No.: 864070-37-1) or (1S)-1,5-Anhydro-1-C-[4-chloro-3-[(4-hydroxyphenyl)methyl]phenyl]-D-glucitol is a heteroaryls metabolite of Dapagliflozin which is an SGLT2 inhibitor useful in the treatment of Type-2 diabetes. Dapagliflozin diminishes the risk of worsening heart failure (HF) and death in patients having HF and lowered ejection fraction. |
| References | Haider, Kashif, et al. “Synthetic Strategy and SAR Studies of C-Glucoside Heteroaryls as SGLT2 Inhibitor: A Review.” European Journal of Medicinal Chemistry, vol. 184, Dec. 2019, p. 111773,https://doi.org/10.1016/j.ejmech.2019.111773.Docherty, Kieran F., et al. “Effects of Dapagliflozin in DAPA-HF according to Background Heart Failure Therapy.” European Heart Journal, vol. 41, no. 25, Mar. 2020, pp. 2379–92,https://doi.org/10.1093/eurheartj/ehaa183. |
