Methyl ester of Obeticholic acid

Methyl ester of Obeticholic acid

Catálogo No.: VL7730001
CAS No.: N/A

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Name: Methyl ester of Obeticholic acid
Catálogo No. VL7730001
CAS No. N/A
Molecular Formula C27H46O4
Molecular Weight 434.65
Status In-stock
IUPAC Name (4R)-4-[(3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate
Description Methyl ester of Obeticholic acid is a synthetic bile acid and has complementary mechanisms of action, this acid is a farnesoid X receptor (FXR) agonist that is active in a wide variety of pathways, it decreases bile acid synthesis, resulting in less buildup of toxic bile acids and less cholestatic damage.
References He, Xiao-Long, et al. “A Facile Synthesis of Ursodeoxycholic Acid and Obeticholic Acid from Cholic Acid.” Steroids, vol. 140, Dec. 2018, pp. 173–78,https://doi.org/10.1016/j.steroids.2018.10.009.‌Brown, Robert S. “Use of Obeticholic Acid in Patients with Primary Biliary Cholangitis.” Gastroenterology & Hepatology, vol. 14, no. 11, Millennium Medical Publishing, 2018, pp. 654–57,www.ncbi.nlm.nih.gov/pmc/articles/PMC6284343/.‌

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